Do Fungi Have Cell Walls? (What You Need to Know)

Most cells in plants and fungi have a cell wall.

fungi and cell wall

These walls are tough, flexible, or rigid, depending on the type.

They function as pressure vessels to prevent cells from over-expanding when water enters.

Karl Rudolphi’s work proved that cells have independent cell walls.

Cell walls act as filters, allowing only the right amount of water to pass through them.

Cells can only absorb so much water at a time.


Chitin in the cell walls of fungi is a simple polysaccharide, a b(1,4)-linked homopolymer of N-acetylglucosamine.

It folds into anti-parallel chains, where hydrogen bonds between the molecules make it stiffer than bone or steel. It is covalently attached to the b(1,3) -glucan, a second load-bearing polysaccharide.

Chitin is a carbohydrate in fungal cell walls, and therefore a promising target for novel antifungal agents. Its characterization in native cell walls has proven difficult.

To tackle this problem, we measured 13C chemical shifts in cell walls of six fungal strains and analyzed them using principal component analysis and linear discriminant analysis. Our findings suggest that chitin has little effect on its function in cell walls.

Although it is important to understand the functions of chitin in fungi, it is also important to understand its role in fungal pathogenesis.

The chitin-related composition of fungal cell walls promotes cellular and humoral responses during infection.

Antibodies directed against mannans and b-glucans are a good indicator of invasive fungal infection.

Moreover, disruption of the cell wall affects cell growth, morphology, and cellular death, which make it a viable antifungal target.

The amount and quality of chitin and chitosan in fungal cell walls is dependent on various factors, including environment, nutritional conditions, and intrinsic characteristics of the species that produces the compounds.

The aim of many researchers is to maximize the yield of chitin and chitosan and reduce its production costs.

Chitin and chitosan produced by submerged culture are competitive with crustacean shell chitin. Nevertheless, more research is necessary to understand the physiochemical properties of fungal cell walls and how to extract them.


Fungal cell walls contain 80 to 90 percent carbohydrates, proteins, and lipids. Most fungal polymers are composed of 1,3 linkage glucose units.

Other fungal polymers contain b-1,6 or a-1,3 linkages. Cell walls of fungi differ in their organization and composition, making them important to a variety of functions. For example, b-1,3-D-glucan is found in the cell walls of Pythium debaryanum.

Fungi cell walls are similar to those of plants, though they contain less cellulose than plants. Plant cell walls contain fibers made of hundreds of glucose molecules grouped into bundles of about 40.

These bundles are embedded in a hydrated network of polysaccharides. The cell wall of a plant is assembled in place by enzymes associated with the cell membrane. In addition to cellulose, the fungal cell wall contains other components such as chitin, glucans, and proteins.

While fungi cells do not contain the same cellular components as humans, these components of the fungal cell wall represent an attractive target for antifungal drugs.

Recent studies demonstrating that the structure and composition of fungal cell walls provide a high-resolution model of the fungal cell wall and provides a strong basis for drug response assessment and development of new wall-targeted antifungals. But what are the components of the fungal cell wall?

In addition to b-glucan, a-1,3-glucans also play important roles in the virulence and resistance of fungi.

Aspergillus neoformans’ capsule is anchored in the cell wall. This is an important role of the cell wall in the fungus’ development and invading the host. However, if the cell wall is devoid of the appropriate components, the fungal infection could become life-threatening for an immunocompromised individual.

The outer cell wall composition of fungi varies, and the structure of the outer layer depends on morphotype. Conidium cells are characterized by a layered structure of hydrophobins and dihydroxynaphtalene melanin.

Other conidium cells lack b-1,3-glucan or chitin. A hyphae cell wall contains a rodlet layer made of hydrophobins.


Glucans are polysaccharides that are the most common structural component of fungal cell walls. They occur as branched, linear, or microfibrillar structures.

The most important glucan is b-1,3-D-glucan, which is synthesized by a complex of enzymes in the plasma membrane.

These enzymes play an important role in the biosynthesis of glucans, which are the main components of fungal cell walls.

Glucans in fungi cell wall components play an important role in the interaction between fungi and their host cells and tissues.

They protect the fungi by altering the cellular immune response, allowing them to grow and spread throughout the host.

These components are also highly immunogenic, resulting in antibodies directed against b-glucans and mannans. Therefore, researchers believe that glucans in fungi cell walls are a promising target for antifungal drugs.

Despite being related and common in plants, glucans are a major component of the cell wall of fungi. They are present in various levels in the cell walls of fungi and bacteria. In plants, glucans are the major component of the cell wall, while the other constituents are minor. Glucans are found in the cell walls of more than 400 species, and their chemistry is closely related to ours.

Several different types of fungi produce their own mannan and chitin-based glycoproteins.

Among these, mannan is the most common and occurs in the outer layer of fungal cell walls. Fungal cell walls are dynamic and contain both chitin and glucans.

Most a-1,3-glucans participate in the formation of rigid cores, although a significant portion of these signals remain in the dynamic domain.

Interestingly, fungal cell walls also form the outer layer of the cells to suffocate the host’s immune system.

Despite the fact that chitin and a-1,3-glucans are rigid, there is no definitive proof that these components are merely supporting structures.

Rather, they may be hydrophobic frames that accommodate the aromatic assembly of pigments.

However, this explanation is still incomplete, as the biomolecules in fungi cell walls are not soluble in water. So, what is the role of glucans in fungi cell walls?


Mucillagmilage is an important part of the fungal cell wall and has several ecological benefits. It serves as a natural antifreeze, protects the protein, and stabilizes the spore cell membrane structure.

Consequently, it plays an important role in the distribution of the fungi in their habitats. In addition, mucilage may be the key to enhanced host pathogenicity.

Hirsutella satumaensis, a spore-forming pathogen, has a thick mucilage layer that contributes to its asexual reproduction.

Researchers have been trying to determine the ecological role of conidial mucilage, but this role remains obscure.

A recent study on the ecology of conidial mucilage in Hirsutella satumaensis demonstrates the importance of mucilage to host adaptation.


Fungal cell walls are composed of different types of polymers that can be classified as chitin and mucilage.

The primary wall layer is composed of cellulose fibers with high tensile strength, which are embedded in a matrix of polysaccharides that contains structural glycoproteins.

In addition to glucans, fungal cell walls may also serve as immune stimulants.

Fungal and plant cells share a similar cell wall design. Plants are composed of cellulose, hemicellulose, and chitin.

Fungal cell walls are different, however, due to the composition of the polysaccharides in the fungi’s cell wall. Fungal cells are composed primarily of chitin, a compound derived from the roots of fungi.